PTEN
- 网络磷酸酶基因；张力蛋白同源物；张力蛋白同源物基因
PTENPTEN
磷酸酶基因
磷酸酶基因(PTEN)是具有磷酸酯酶活性的抑癌基因，它不仅参与多种信号传导途径及调控细胞周期，而且在细胞黏附、分化、 …
张力蛋白同源物
PIP3受磷酸酶和张力蛋白同源物（PTEN）的负性调节。AKT被某些酶充分激活，包括PDK1，mTORC2，和IRS - 1，接着AKT …
张力蛋白同源物基因
磷酸酶与张力蛋白同源物基因(PTEN)是定位于10q23的具有双重磷酸酶活性的抑癌基因,其缺失或失活常会导致肿瘤的发生.PTE…
抑癌基因
【摘要】 目的 探讨抑癌基因（PTEN）、凋亡抑制基因（survivin）、垂体腺瘤转化基因（PTTG）表达与垂体腺瘤侵袭性的关 …
肿瘤抑制基因
岭南心血管病杂志 2007年04期 肿瘤抑制基因(PTEN); 钙; 钙调神经磷酸酶; 血管紧张素Ⅱ; 心肌肥大; 6. 目的探讨中药复方益气 …
张力蛋白同源基因
...生长因子(VEGF)和第10号染色体缺失的磷酸酶和张力蛋白同源基因(PTEN)在乳腺癌原发灶及转移灶中的表达,从而探讨它们 …
1
Now an international group of researchers has found at least one reason why. BRCA1 inactivates a tumor suppressor gene known as PTEN.
现今一支国际研究小组发现原因之一是BRCA1会抑制另一种名为PTEN的基因，而PTEN基因是人体内抑制肿瘤的基因。
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Results The PTEN and MGMT protein were all expressed in nucleus r of ductal cellula epithelial is.
结果PTEN与MGMT表达均位于乳腺导管上皮细胞核。
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Mutations of PTEN gene do not play a major role in the carcinogenesis of oesophageal squamous cell carcinoma.
PTEN基因突变在食管癌的发生、发展中不起主要作用；
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Objective: To investigate the expression of PTEN protein and analyse DNA content in laryngeal papilloma and its malignant transformation.
目的：研究在喉乳头状瘤及其癌变组织中PTEN蛋白表达及DNA含量的变化，探讨喉乳头状瘤癌变的机制。
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Role of PTEN in tumorigenesis has been a hotspot of research in tumor domain.
过去，PTEN在肿瘤发生发展中的作用是研究的热点。
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Objective To detect the expression of a novo tumor suppressor gene PTEN and DNA direct repair enzyme MGMT in gynecomastia .
目的观察抑癌基因PTEN和DNA直接修复酶MGMT在男性乳房发育症（GM）乳腺中的表达。
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Objective To investigate the loss expression and its clinical significance of PTEN gene in bladder transitional cell carcinoma.
目的探讨PTEN基因在膀胱移行细胞癌中的表达缺失及其临床意义。
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Objective It is to discuss the expression and significance of a new tumor suppressor gene PTEN in uterine cervix cancer.
目的探讨一种新的抑癌基因PTEN在人宫颈癌中的表达及意义。
9
The researchers found that inactivating the PTEN gene in mice led to the formation of the malignant tumor associated with BRCA1 mutations.
研究人员发现，灭活小鼠的PTEN基因能诱发与BRCA1突变相关的恶性肿瘤的形成。
10
Invasion and metastasis are two important characters of malignant tumor, in two process, the PTEN and VEGF play an important role.
侵袭和转移是恶性肿瘤的两大特性，肾癌也不例外，在此过程中，PTEN和VEGF发挥重要的作用。
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Objective To investigate the expression of tumor suppressor gene PTEN in breast carcinomas and its significance.
目的研究肿瘤抑制基因PTEN在乳腺癌组织中的表达及临床意义。
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COX multivariate survival analysis: TNM stage, PTEN and Ezrin expression is an independent prognostic risk factors in NSCLC patients (p05).
COX模型多因素生存分析显示：TNM分期、PTEN和Ezrin表达是影响NSCLC患者预后的独立危险因素（p0.05）。
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Mutation rate of PTEN had a relation with tumor pathological grades.
膀胱癌PTEN的突变率可能与肿瘤的病理学分级有关。
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Objective: To explore the expression of PTEN gene in colorectal carcinoma and its effect on angiogenesis.
摘要目的：探讨人类大肠癌中PTEN基因的表达规律及在大肠癌微血管生成中的作用。
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Objective To investigate expression and significance of tumor suppressor gene PTEN in esophageal carcinoma.
目的探讨抑癌基因PTEN在食管癌中的表达及临床意义。
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To investigate the correlation between the polymorphism of PTEN gene and the prognosis of HCC(Hepatocelluar Carcinoma) patients.
探讨PTEN基因多态性与家族聚集性肝癌预后的关系。
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Conclusion: The over-expression of IGF-1R and down-regulation of PTEN expression may play a role in pathologic scar.
结论：IGF-1R的高表达和PTEN的表达下调在病理性瘢痕形成中起重要作用。
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Conclusion: PTEN gene transfection combined with L-OHP has obvious inhibitory effect on cholangiocarcinoma cell line in vitro.
结论：PTEN基因转染生物治疗联合奥沙利铂化疗对人胆管癌细胞生长具有显著的抑制作用。
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Conculsion: PTEN protein abnormally expressed probably plays an important role in the laryngeal papilloma malignant transformation.
结论：PTEN蛋白异常表达及DNA含量变化可能在喉乳头状瘤恶变机制中发挥重要作用。
20
Although PTEN is mutated or deleted in many tumours, deregulation of the PI3K-PTEN network also occurs through other mechanisms.
尽管PTEN基因的突变或删除在许多肿瘤，撤销PI3K的，PTEN基因网络还通过其他机制发生。
21
Conclusion As a new tumor suppressor gene, PTEN are related to the occurrence and development of the malignant breast cancer.
结论PTEN作为一种新型的抑癌基因，其突变与缺失可能与恶性乳腺肿瘤的发生发展密切相关。
22
In most cases, the protein that PTEN produces was undetectable in tumor cells, but clearly present in nearby normal cells.
在大多数病例中由PTEN导致的蛋白在肿瘤细胞中无法检测出，但是可以在正常细胞中能够检测到。
23
PTEN activity is low early during development, allowing cell proliferation.
PTEN的活动度在发育的早期低，从而允许细胞的分化增殖。
24
As a tumor-suppressor gene, phosphatase and tensin homology deleted on chromosome 10(PTEN) regulates negatively the growth of tumor cells.
第10号染色体同源丢失性磷酸酶-张力蛋白基因（PTEN）作为肿瘤抑制基因，可以负性调节肿瘤细胞的生长。
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PTEN then turns on when growth is completed, inhibiting mTOR and precluding any ability to regenerate.
然后，当生长完成的时候，PTEN被打开了开关，抑制mTOR并阻止再生能力的发挥。
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Objective To investigate the role of anti-oncogene PTEN in the tumorigenesis and development of parotid pleomorphic adenoma.
目的探讨抑癌基因PTEN在腮腺多形性腺瘤的发生、发展过程中的作用。
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ObjectiveTo investigate the expression and significance of PTEN and P-ERK protein in cutaneous squamous cell carcinoma.
目的：探讨PTEN和P-ERK蛋白在皮肤鳞状细胞癌中的表达及意义。
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Conclusion The low expression and mutation of PTEN gene probably promote the occurrence and development of glioma.
结论：PTEN基因低表达及基因突变可能对胶质瘤发生、发展有促进作用。
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Methods Immunohistochemistry ( S - P) was app lied to measure the expression of PTEN and PCNA in 40 cases with primary glioma.
方法应用免疫组化S-P法检测40例原发胶质瘤中抑癌基因PTEN，增殖细胞核抗原PCNA的表达。
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The cells may also lose or inactivate the tumor suppressor gene PTEN.
癌细胞也可能甩掉或关闭肿瘤抑制基因PTEN。