histone
美 ['hɪstoʊn]英 ['hɪstəʊn]
- n.【生化】组蛋白
- 网络组织蛋白；抗组蛋白抗体；H组蛋白
复数：histones
histonehistone
组蛋白
组蛋白（histone）是指所有真核生物的细胞核中，与DNA结合存在的碱性蛋白质的总称。其分子量约10 000～20 000。
组织蛋白
组织蛋白(Histone)：在人体生理功能中的重要性不可言喻，一般来说可以控制细胞生长，因此被认为具有预防癌症的效果。纤 …
抗组蛋白抗体
5、抗组蛋白抗体（HISTONE）阴性6、抗SM抗体（SMDL） 阴性7、抗剪接体复合蛋白抗体（UI-SNRNP）阴性8、抗SS-A/R…
H组蛋白
磷酸化组蛋白H3,Ph... ... ) acetylated histone H3 乙酰化组蛋白H3 ) Histone H3 组蛋白H3 ) Phospho-histone H3 磷酸化组蛋白H…
组蛋白-预订
Histone 组蛋白（价格优惠） sg11550 ... MGsg11551 Histone 组蛋白-预订 1G Histone 组蛋白-预订 ...
组蛋白形成的八聚体
核小体是由近乎球状的组蛋白形成的八聚体（histone）（H2a、H2b、H3和H4）和在其外围绕两圈的DNA所构成。DNA的约20…
1
In contrast to the universal nature of the DNA code, the histone language and its decoding machinery differ among animals, plants and fungi.
与此相反的普遍性的DNA代码，组的语言和其解码机制不同的动物，植物和真菌。
2
Genes can also be silenced by modification of the histone proteins that make up the "smart stuffing" in chromosomes.
基因也可以通过组蛋白的修饰被沉默，组蛋白是组装染色体的“填料”。
3
These patterns are referred to as 'the histone code'.
这些机制被称为“组蛋白密码”。
4
Recent studies have mapped histone modifications across the Saccharomyces cerevisiae genome.
最近的研究跨酿酒酵母基因组比对了组蛋白修饰。
5
Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.
靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。
6
When methyl groups are added to a histone, they modify its properties and alter the frequency at which a particular gene is expressed.
当甲基加到组蛋白后，这些基团会修饰它的性质并改变它上面特定基因的表达频率。
7
The incorporation of histone variants most probably has epigenetic consequences and contributes to architectural changes in chromosomes.
组蛋白变体的合并最可能具有表观影响，并有助于染色体的结构化改变。
8
Dr. Fischer's research shows that when young mice are learning, an acetyl group binds to a particular point on the histone protein.
费舍尔博士的研究显示，当一只年轻的白鼠在学习时，一个乙酰基群在组蛋白上抱成特殊的节点。
9
A small molecule called an acetyl group attaches to a particular histone known as H4.
一个小小的分子称作一个乙酰基团，它黏在一个称作H4的特殊组蛋白上。
10
The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.
组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。
11
DNA wraps around histone spools to form a rosarylike chain, which is then twisted into a bundle[ see illustration on opposite page].
DNA缠绕在组织蛋白构成的线轴上，形成类似念珠的链子，然后再绕成一束（见上页〈因音量的控制〉。
12
RSEG is also able to incorporate a control sample and find genomic regions with differential histone modifications between two samples.
RSEG也能够包含一个对照样本，并找到两个样本间具有差异组蛋白修饰的基因组区域。
13
These alterations in the histone code may alter gene expression pattern to set the stage for leukemogenesis.
组蛋白密码的这些改变可能改变基因表达模式以设定白血病发生状态。
14
Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。
15
Both DNA methylation and histone modification are involved in establishing patterns of gene repression during development.
这两个DNA甲基化和组蛋白修饰参与建立模式的发育过程中基因的镇压。
16
Background: Histone acetylation as an epigenetic change is widely studied in cancer.
目的：组蛋白乙酰化作为一种后生变化在肿瘤领域被广泛研究。
17
The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity.
本发明提供了用于抑制组蛋白脱乙酰基酶酶活性的化合物和方法。
18
The hypothesis of "Histone code" suggests an existing way of program information of eukaryotic gene control.
“组蛋白编码”假说提示了真核生物基因调控的程序性信息的存在方式。
19
Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein.
组蛋白标记经由一个染色质结合蛋白质，通过影响剪接调控子的招募而影响剪接结果。
20
Objective: To improve the synthetic procedure of the histone deacetylase (HDAC) inhibitor SAHA.
目的：改进组蛋白去乙酰化酶抑制剂SAHA的合成工艺。
21
Covalent modifications of histone tails play a key role in the regulation of chromatin structure and control of transcriptional activity.
染色体组蛋白的共价修饰在调节染色体结构，控制基因的转录等方面发挥重要的作用。
22
As in the Alzheimer's mice, drugs that boosted histone acetylation improved the older mice's performance on tests of rodent cognition.
如同阿尔茨海默病鼠，增强组蛋白乙酰化的药物改善了年老小鼠在认知测试中的表现。
23
The canonical histone proteins are encoded by replication-dependent genes and must rapidly reach high levels of expression during S phase.
规范组蛋白编码的复制依赖基因和必须迅速达到高水平的表达在S期。
24
Some portions of the double stranded DNA were opened. The binding of histone to DNA was observed with molecular combing.
直接观察到了单个DNA分子在拉伸力作用下的熔化现象，局部双链被打开。
25
Typical patterns of histone methylations exhibited at promoters, insulators, enhancers, and transcribed regions are identified.
表现在启动子、绝缘子、增强子和转录区域的组蛋白甲基化的典型模式被确定。
26
Chromosome banding patterns are correlated with unique patterns of histone modifications.
染色体带型和组蛋白修饰的特有模式相关。
27
DNA methylation has an important role in transcriptional regulation, togethering with histone modification and chromatin remodeling.
DNA甲基化在基因转录过程中扮有重要角色，并与组蛋白修饰、染色质构型重塑共同参与转录调控。
28
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors.
认识到开发新颖治疗剂的要求，本发明提供新颖组蛋白去乙酰化酶抑制剂。
29
histone status renders DNA sequences accessible or inaccessible for transcription.
转录过程中，组蛋白的状态能够影响DNA序列相互靠近或者远离。
30
This review mainly focuses on recent advances in histone methylation effector protein's function mechanism.
文章从组蛋白甲基化效应分子的作用机制方面综述了这一领域的研究进展。