trpv1

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trpv1

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Scientists have long known that the nervous system receptor known as TRPV1 can affect sensations of pain in the body. 科学家一直知道神经系统受体如已知的TRPV1能影响机体的疼痛感觉。
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The team found that this compound activated TRPV1 channels - which alone triggered long-term depression in the brain tissue. 她的团队发现这个成分激活TRPV1通道,它可以独自激发脑组织的长时程抑郁。
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Study on role of TRPV1 and its mechanisms will help us to understand pain physiology and to develop new analgesic drugs. 深入研究TRPV1的作用机制,有助于理解痛觉生理和开发新型镇痛药物。
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Thus, TRPV1 is an excellent target for a rational pharmacological treatment of pain. 因此,TRPV1是一个很好的目标,合理的药物治疗的痛苦。
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Pain relief occurs after what is thought to be a reduction in TRPV1-expressing nociceptive nerve endings. 疼痛缓解后发生了被认为是在TRPV1受体,表达痛觉神经末梢减少。
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When scientists discovered that the VR1 receptor was a member of the larger family of TRP ion channels, the VR1 receptor was renamed TRPV1. 科学家们发现VR1受体是瞬时受体电位通道(TRPionchannels)家族的一员,于是VR1受体又被命名为TRPV1。
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TRPV1 can detect noxious stimulus and convert it into action potentials traveling to the central and forming pain sensation. TRPV1能够感受伤害性刺激,将之转化为动作电位,传至中枢形成痛觉。
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Other drugs aimed at reducing pain and inflammation by blocking or activating TRPV1 receptors are in the research pipeline. 其他药物的目的在于通过阻断或激活TRPV1受体减少疼痛和炎症,这还在研究中。
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Further, rimonabant entirely blocked long-term depression by blocking TRPV1 channels. 另外,利莫那班通过阻断TRPV1通道完全阻断长时程抑郁。
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When TRPV1 is activated or sensitized by proton, bradykinin, or endovanilloids released during myocardial ischemia (MI), it leads to angina. 心肌缺血时释放的质子,缓激肽,或内源性香草酸均能激动或致敏TRPV1,导致心绞痛。